Tenuifolin

• CAT Number: R025088
• CAS Number: 20183-47-5
• Molecular Formula: C36H56O12
• Molecular Weight: 680.82
• Purity: ≥95%
• Synonyms: (2S,3R,4S,4aR,6aR,6bR,8aS,12aS,14aR,14bR)-2-hydroxy-6b-(hydroxymethyl)-4,6a,11,11,14b-pentamethyl-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicene-4,8a-dicarboxylic acid
• InChI: InChI=1S/C36H56O12/c1-31(2)10-11-35(30(45)46)12-13-36(17-38)18(19(35)14-31)6-7-22-32(3)15-20(39)27(34(5,29(43)44)23(32)8-9-33(22,36)4)48-28-26(42)25(41)24(40)21(16-37)47-28/h6,19-28,37-42H,7-17H2,1-5H3,(H,43,44)(H,45,46)/t19-,20-,21+,22+,23+,24+,25-,26+,27-,28-,32+,33+,34-,35-,36-/m0/s1
• InChIKey: DBJLNNAUDGIUAE-YGIRLYIESA-N
• SMILES: CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CC(C(C5(C)C(=O)O)OC6C(C(C(C(O6)CO)O)O)O)O)C)C)C2C1)CO)C(=O)O)C

Tenuifolin(CAT: R025088) is a bioactive saponin derived from Polygala tenuifolia (Yuan Zhi), a traditional Chinese medicinal herb. It has attracted significant attention for its neuroprotective, cognitive-enhancing, antidepressant, and anti-inflammatory properties. Research shows that Tenuifolin can modulate neurotransmitter systems, inhibit acetylcholinesterase, and protect neurons from oxidative damage, making it a promising candidate for Alzheimer’s disease and other neurodegenerative disorders. It has also been shown to improve memory and learning in experimental models while reducing stress-related symptoms. With its multifaceted pharmacological activities, Tenuifolin serves as an important natural compound for studies in neurology, psychiatry, and natural product-based therapeutic development.