CONTACT US
Home > Apoptosis>Bioactive Chemicals> > Temozolomide
Temozolomide

Temozolomide

  • CAT Number: A001097
  • CAS Number: 85622-93-1
  • Molecular Formula: C6H6N6O2
  • Molecular Weight: 194.2
  • Purity: ≥95%
Inquiry Now

Temozolomide (CAT: A001097), also known as SCH 52365, MB39831, and RP46161, is a triazene analog of dacarbazine with antineoplastic activity. As a cytotoxic alkylating agent, the cytotoxicity of MTIC is due primarily to the methylation of DNA at the O6 and N7 positions of guanine, resulting in the inhibition of DNA replication. This product is used for medical research and development and other scientific research purposes.

Catalog Number A001097
CAS Number 85622-93-1
Molecular Formula

C6H6N6O2

Purity 95%
Target DNA Alkylating
Solubility >6.6mg/mL in DMSO
Storage 3 years -20C powder
Overview of Clinical Research

<span style=”font-size:12px;”><span style=”font-family:arial,helvetica,sans-serif;”><span style=”color:#000000;”>Temozolomide is an alkylating agent and a DNA cross linking agent as well as a DNA synthesis inhibitor. It has been granted for the orphan drug status in&nbsp;Glioblastoma; Anaplastic astrocytoma; Malignant melanoma.</span></span></span>

IUPAC Name 3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
InChI InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)
InChIKey BPEGJWRSRHCHSN-UHFFFAOYSA-N
SMILES CN1N=NC2=C(C(N)=O)N=CN2C1=O
Reference

<br />
1:Metabolomics of Therapy Response in Preclinical Glioblastoma: A Multi-Slice MRSI-Based Volumetric Analysis for Noninvasive Assessment of Temozolomide Treatment. Arias-Ramos N, Ferrer-Font L, Lope-Piedrafita S, Mocioiu V, Juli&agrave;-Sap&eacute; M, Pumarola M, Ar&uacute;s C, Candiota AP.Metabolites. 2017 May 18;7(2). pii: E20. doi: 10.3390/metabo7020020. PMID: 28524099<br />
2:A phase II trial of arsenic trioxide and temozolomide in combination with radiation therapy for patients with malignant gliomas. Kumthekar P, Grimm S, Chandler J, Mehta M, Marymont M, Levy R, Muro K, Helenowski I, McCarthy K, Fountas L, Raizer J.J Neurooncol. 2017 May 16. doi: 10.1007/s11060-017-2469-x. [Epub ahead of print] PMID: 28510787<br />
3:Tumour exosomes from cells harbouring PTPRZ1-MET fusion contribute to a malignant phenotype and temozolomide chemoresistance in glioblastoma. Zeng AL, Yan W, Liu YW, Wang Z, Hu Q, Nie E, Zhou X, Li R, Wang XF, Jiang T, You YP.Oncogene. 2017 May 15. doi: 10.1038/onc.2017.134. [Epub ahead of print] PMID: 28504721<br />
4:MiR-181b modulates chemosensitivity of glioblastoma multiforme cells to temozolomide by targeting the epidermal growth factor receptor. Chen Y, Li R, Pan M, Shi Z, Yan W, Liu N, You Y, Zhang J, Wang X.J Neurooncol. 2017 May 13. doi: 10.1007/s11060-017-2463-3. [Epub ahead of print] PMID: 28501897<br />
5:Efficacy and safety of long-term therapy for high-grade glioma with temozolomide: a meta-analysis. Xu W, Li T, Gao L, Zheng J, Shao A, Zhang J.Oncotarget. 2017 Apr 24. doi: 10.18632/oncotarget.17401. [Epub ahead of print] PMID: 28501853 Free Article<br />
6:Dovitinib enhances temozolomide efficacy in glioblastoma cells. Thanasupawat T, Natarajan S, Rommel A, Glogowska A, Bergen H, Krcek J, Pitz M, Beiko J, Krawitz S, Verma IM, Ghavami S, Klonisch T, Hombach-Klonisch S.Mol Oncol. 2017 May 13. doi: 10.1002/1878-0261.12076. [Epub ahead of print] PMID: 28500786 Free Article<br />
7:Clinical Pharmacokinetics and Mass Balance of Veliparib in Combination with Temozolomide in Subjects with Nonhematologic Malignancies. Nuthalapati S, Munasinghe W, Giranda V, Xiong H.Clin Pharmacokinet. 2017 May 11. doi: 10.1007/s40262-017-0547-z. [Epub ahead of print] PMID: 28497258<br />
8:Comparative analysis of the effects of a sphingosine kinase inhibitor to temozolomide and radiation treatment on glioblastoma cell lines. Oancea-Castillo LR, Klein C, Abdollahi A, Weber KJ, R&eacute;gnier-Vigouroux A, Dokic I.Cancer Biol Ther. 2017 May 11:0. doi: 10.1080/15384047.2017.1323583. [Epub ahead of print] PMID: 28494176<br />
9:A case series of salvage CCNU in high-grade glioma who have previously received temozolomide from a tertiary care institute in Mumbai. Patil VM, Abhinav R, Tonse R, Epari S, Gupta T, Jalali R.Indian J Cancer. 2016 Oct-Dec;53(4):558-561. doi: 10.4103/0019-509X.204774. PMID: 28485350 Free Article<br />
10:Combination therapy with micellarized cyclopamine and temozolomide attenuate glioblastoma growth through Gli1 down-regulation. Liu YJ, Ma YC, Zhang WJ, Yang ZZ, Liang DS, Wu ZF, Qi XR.Oncotarget. 2017 Apr 18. doi: 10.18632/oncotarget.17205. [Epub ahead of print] PMID: 28477008 Free Article

Request a Quote

Contact Us at MuseChem

We are committed to providing you with reliable, cost-effective solutions for your chemical needs, while ensuring your safety and comfort. Our team of experts is always available to answer your questions and help you navigate the complexities of the chemical industry.

Whether you're looking for a specific product or need help with a custom synthesis project, we're here to help you discover a new world of chemical possibilities. Contact us today to learn more about how we can assist you with all of your chemical needs.

Our goal is to make the process of ordering chemicals as seamless and hassle-free as possible. Let us know how we can assist you, and we'll get back to you as soon as possible. We look forward to hearing from you!