For research use only. Not for therapeutic Use.
TEI-9648（Cat No.:I044377）is a potent and selective antagonist of MDM2, a negative regulator of the tumor suppressor protein p53. By blocking the MDM2-p53 interaction, TEI-9648 stabilizes and activates p53, promoting cell cycle arrest and apoptosis in cancer cells with wild-type p53. This compound has demonstrated significant antitumor activity in preclinical models, especially in cancers retaining functional p53. TEI-9648 serves as a valuable research tool for studying p53-mediated tumor suppression and supports the development of targeted cancer therapies aiming to reactivate p53 in malignancies driven by MDM2 overexpression.
| CAS Number | 173388-21-1 |
| Synonyms | (5R)-5-[(2R)-2-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(3S,5R)-3,5-dihydroxy-2-methylidenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]propyl]-3-methylideneoxolan-2-one |
| Molecular Formula | C27H38O4 |
| Purity | ≥95% |
| IUPAC Name | (5R)-5-[(2R)-2-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(3S,5R)-3,5-dihydroxy-2-methylidenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]propyl]-3-methylideneoxolan-2-one |
| InChI | InChI=1S/C27H38O4/c1-16(12-22-13-17(2)26(30)31-22)23-9-10-24-19(6-5-11-27(23,24)4)7-8-20-14-21(28)15-25(29)18(20)3/h7-8,16,21-25,28-29H,2-3,5-6,9-15H2,1,4H3/b19-7+,20-8-/t16-,21-,22-,23-,24+,25+,27-/m1/s1 |
| InChIKey | SAODSJHDCZTVAT-JXJLEVNFSA-N |
| SMILES | C[C@H](C[C@@H]1CC(=C)C(=O)O1)[C@H]2CC[C@@H]\3[C@@]2(CCC/C3=C\C=C/4\C[C@H](C[C@@H](C4=C)O)O)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
