Tegoprubart

• CAT Number: I040380
• CAS Number: 2628092-47-5
• Purity: ≥95%

Tegoprubart(CAT: I040380) (also known as AT-1501) is a humanized IgG1κ monoclonal antibody that selectively binds to CD40 ligand (CD40L), a crucial costimulatory molecule involved in T-cell activation and immune regulation. By blocking the CD40–CD40L interaction, Tegoprubart inhibits both cellular and humoral immune responses without broad immunosuppression. It has demonstrated strong potential in treating autoimmune diseases, neuroinflammatory disorders, and preventing transplant rejection. Preclinical and clinical studies show that it is well tolerated and effective in preserving graft function and reducing inflammatory markers. Supplied at high purity, Tegoprubart is ideal for research in immunotherapy, transplantation, and autoimmune regulation.