TD1092

• CAT Number: I042381
• Molecular Formula: C55H70N8O9
• Molecular Weight: 987.19
• Purity: ≥95%
• Synonyms: (3S)-2-[(2S)-3,3-dimethyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-7-[8-[[1-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]azetidine-3-carbonyl]amino]octoxy]-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-3,4-dihydro-1H-isoquinoline-3-carboxamide
• InChI: InChI=1S/C55H70N8O9/c1-33(56-5)48(65)60-47(55(2,3)4)54(71)62-32-36-27-39(21-19-35(36)28-45(62)51(68)58-43-18-14-16-34-15-10-11-17-40(34)43)72-26-13-9-7-6-8-12-25-57-49(66)37-30-61(31-37)38-20-22-41-42(29-38)53(70)63(52(41)69)44-23-24-46(64)59-50(44)67/h10-11,15,17,19-22,27,29,33,37,43-45,47,56H,6-9,12-14,16,18,23-26,28,30-32H2,1-5H3,(H,57,66)(H,58,68)(H,60,65)(H,59,64,67)/t33-,43+,44?,45-,47+/m0/s1
• InChIKey: SZHRKMBISSMURE-LXHHKSBKSA-N
• SMILES: CC(C(=O)NC(C(=O)N1CC2=C(CC1C(=O)NC3CCCC4=CC=CC=C34)C=CC(=C2)OCCCCCCCCNC(=O)C5CN(C5)C6=CC7=C(C=C6)C(=O)N(C7=O)C8CCC(=O)NC8=O)C(C)(C)C)NC

TD1092 (Cat No.: I042381) is a potent and selective small-molecule inhibitor targeting fibroblast growth factor receptor 4 (FGFR4), a receptor tyrosine kinase involved in cell proliferation, differentiation, and survival. FGFR4 is frequently overexpressed in certain cancers, such as hepatocellular carcinoma. By selectively inhibiting FGFR4 signaling, TD1092 disrupts oncogenic pathways, reducing tumor growth and progression. Its high specificity minimizes off-target effects, making it a valuable tool for cancer research. TD1092 supports the development of targeted therapies for FGFR4-driven malignancies and personalized oncology strategies.

Reference

[1]. Park S, et al. Discovery of pan-IAP degraders via a CRBN recruiting mechanism. Eur J Med Chem. 2023 Jan 5;245(Pt 2):114910.
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