For research use only. Not for therapeutic Use.
TCO-PEG4-DBCO（Cat No.:I016045）is a heterobifunctional PEG linker featuring a trans-cyclooctene (TCO) group on one end and a dibenzocyclooctyne (DBCO) on the other. The TCO moiety undergoes rapid, catalyst-free inverse-electron-demand Diels–Alder (IEDDA) reactions with tetrazines, while the DBCO enables copper-free strain-promoted azide–alkyne cycloaddition (SPAAC) with azides. Together, they provide dual orthogonal click handles for sequential or modular bioconjugation. The PEG4 spacer enhances solubility, reduces steric hindrance, and improves flexibility, supporting high-efficiency reactions. This reagent is highly valuable in bioorthogonal labeling, drug delivery, diagnostic probe design, and advanced biomaterials research.
| CAS Number | 1801863-88-6 |
| Synonyms | [(4Z)-cyclooct-4-en-1-yl] N-[2-[2-[2-[2-[3-[[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]amino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethyl]carbamate |
| Molecular Formula | C38H49N3O8 |
| Purity | ≥95% |
| IUPAC Name | [(4Z)-cyclooct-4-en-1-yl] N-[2-[2-[2-[2-[3-[[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]amino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethyl]carbamate |
| InChI | InChI=1S/C38H49N3O8/c42-36(39-20-18-37(43)41-30-33-12-7-6-10-31(33)16-17-32-11-8-9-15-35(32)41)19-22-45-24-26-47-28-29-48-27-25-46-23-21-40-38(44)49-34-13-4-2-1-3-5-14-34/h1-2,6-12,15,34H,3-5,13-14,18-30H2,(H,39,42)(H,40,44)/b2-1- |
| InChIKey | MXNJAXPSMJDOOY-UPHRSURJSA-N |
| SMILES | C1C/C=C\CCC(C1)OC(=O)NCCOCCOCCOCCOCCC(=O)NCCC(=O)N2CC3=CC=CC=C3C#CC4=CC=CC=C42 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
