For research use only. Not for therapeutic Use.
TCID (CAT: I011124) is a potent and selective inhibitor of neuronal ubiquitin C-terminal hydrolase UCH-L3, with an IC₅₀ of 0.6 μM. It shows significantly lower activity toward UCH-L1 (IC₅₀ = 75 μM), highlighting its selectivity. In neuronal studies, TCID effectively diminishes glycine transporter GlyT2 ubiquitination in brainstem and spinal cord primary neurons, demonstrating its role in modulating ubiquitin-dependent pathways. At 10 μM for 1–2 hours, TCID reduces GlyT2 ubiquitination, providing a useful tool for probing ubiquitin hydrolase biology and synaptic protein regulation. Its potency and selectivity make TCID valuable in neurobiology and ubiquitin signaling research.
| CAS Number | 30675-13-9 |
| Synonyms | 4,5,6,7-tetrachloroindene-1,3-dione |
| Molecular Formula | C9H2Cl4O2 |
| Purity | ≥95% |
| IUPAC Name | 4,5,6,7-tetrachloroindene-1,3-dione |
| InChI | InChI=1S/C9H2Cl4O2/c10-6-4-2(14)1-3(15)5(4)7(11)9(13)8(6)12/h1H2 |
| InChIKey | IDLAOWFFKWRNHB-UHFFFAOYSA-N |
| SMILES | C1C(=O)C2=C(C1=O)C(=C(C(=C2Cl)Cl)Cl)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
