For research use only. Not for therapeutic Use.
TCA1 (Cat No.: I045495) is a small-molecule antimycobacterial agent with potent activity against Mycobacterium tuberculosis, including drug-resistant strains. It targets the bacterial enzyme decaprenylphosphoryl-β-D-ribose 2′-epimerase (DprE1), essential for arabinan biosynthesis in the mycobacterial cell wall. By inhibiting DprE1, TCA1 disrupts cell wall formation, leading to bacterial death. It has shown efficacy in both replicating and non-replicating M. tuberculosis populations. TCA1 is used in tuberculosis drug discovery as a lead compound for developing novel therapeutics aimed at overcoming resistance to existing TB treatments.
| CAS Number | 864941-32-2 |
| Synonyms | ethyl N-[2-(1,3-benzothiazole-2-carbonylamino)thiophene-3-carbonyl]carbamate |
| Molecular Formula | C16H13N3O4S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C16H13N3O4S2/c1-2-23-16(22)19-12(20)9-7-8-24-14(9)18-13(21)15-17-10-5-3-4-6-11(10)25-15/h3-8H,2H2,1H3,(H,18,21)(H,19,20,22) |
| InChIKey | ISNBJLXHBBZKSL-UHFFFAOYSA-N |
| SMILES | CCOC(=O)NC(=O)C1=C(SC=C1)NC(=O)C2=NC3=CC=CC=C3S2 |
| Reference | [1]. Feng Wang, et al. Identification of a small molecule with activity against drug-resistant and persistent tuberculosis. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2510-7. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
