TC11

• CAT Number: I045490
• CAS Number: 100823-03-8
• Molecular Formula: C20H22N2O2
• Molecular Weight: 322.40
• Purity: ≥95%
• Synonyms: 5-amino-2-[2,6-di(propan-2-yl)phenyl]isoindole-1,3-dione
• InChI: InChI=1S/C20H22N2O2/c1-11(2)14-6-5-7-15(12(3)4)18(14)22-19(23)16-9-8-13(21)10-17(16)20(22)24/h5-12H,21H2,1-4H3
• InChIKey: NRPIRIUWEKTNGQ-UHFFFAOYSA-N
• SMILES: CC(C)C1=C(C(=CC=C1)C(C)C)N2C(=O)C3=C(C2=O)C=C(C=C3)N

TC11 (Cat No.: I045490) is a small-molecule inhibitor that targets cyclin-dependent kinase 9 (CDK9), a key regulator of transcription elongation via phosphorylation of RNA polymerase II. By inhibiting CDK9, TC11 suppresses transcription of anti-apoptotic and pro-survival genes, such as MCL-1, making it relevant in cancer therapy research. It has shown potential in inducing apoptosis in leukemia and other malignancies dependent on continuous transcriptional activity. TC11 is used as a chemical probe in epigenetics, oncology, and transcription biology to study CDK9-mediated gene regulation and therapeutic targeting.

Reference

[1]. Ichikawa D, et al. A phenylphthalimide derivative, TC11, induces apoptosis by degrading MCL1 in multiple myeloma cells. Biochem Biophys Res Commun. 2020;521(1):252-258.
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[2]. Shiheido H, et al. A phthalimide derivative that inhibits centrosomal clustering is effective on multiple myeloma. PLoS One. 2012;7(6):e38878.
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