TC-E 5003

• CAT Number: M073966
• CAS Number: 17328-16-4
• Molecular Formula: C16H14Cl2N2O4S
• Molecular Weight: 401.26
• Purity: ≥95%
• Synonyms: N,N/’-(sulfonylbis(4,1-phenylene))bis(2-chloroacetamide)
• Target: Histone Methyltransferase
• Solubility: Soluble in DMSO > 10 mM
• Storage: Store at +4C
• IUPAC Name: 2-chloro-N-[4-[4-[(2-chloroacetyl)amino]phenyl]sulfonylphenyl]acetamide
• InChI: InChI=1S/C16H14Cl2N2O4S/c17-9-15(21)19-11-1-5-13(6-2-11)25(23,24)14-7-3-12(4-8-14)20-16(22)10-18/h1-8H,9-10H2,(H,19,21)(H,20,22)
• InChIKey: SHRCVZJKZJGIHQ-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1NC(=O)CCl)S(=O)(=O)C2=CC=C(C=C2)NC(=O)CCl

TC-E 5003(Cat No.:M073966) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor, with an IC50 (half-maximal inhibitory concentration) of 1.5 μM. Notably, this compound does not display inhibitory activity against CARM1 and Set7/9 methyltransferases. Its action involves the suppression of PRMT1, a key enzyme involved in protein arginine methylation, which has implications for various cellular processes including gene expression regulation and protein function. In experimental settings, TC-E 5003 has been shown to inhibit the growth of MCF7a breast cancer cells and LNCaP prostate cancer cells, suggesting potential applications in cancer research.