For research use only. Not for therapeutic Use.
TBAP-001（Cat No.:I014902）is a selective antagonist of the prostaglandin E2 receptor subtype EP4, a G-protein-coupled receptor implicated in inflammation, pain, tumor progression, and immune regulation. By blocking EP4-mediated signaling, TBAP-001 inhibits downstream pathways such as cAMP production and PKA activation, thereby reducing pro-inflammatory cytokine release and modulating immune cell function. Preclinical studies highlight its potential in cancer, autoimmune disease, and chronic inflammatory conditions. TBAP-001 serves as a valuable research tool for exploring prostaglandin biology, EP4 receptor pharmacology, and therapeutic strategies targeting inflammation and tumor microenvironment.
| CAS Number | 1777832-90-2 |
| Synonyms | 1-[5-tert-butyl-2-(3-fluorophenyl)pyrazol-3-yl]-3-[2-fluoro-4-[(3-oxo-4H-pyrido[2,3-b]pyrazin-8-yl)oxy]phenyl]urea |
| Molecular Formula | C27H23F2N7O3 |
| Purity | ≥95% |
| IUPAC Name | 1-[5-tert-butyl-2-(3-fluorophenyl)pyrazol-3-yl]-3-[2-fluoro-4-[(3-oxo-4H-pyrido[2,3-b]pyrazin-8-yl)oxy]phenyl]urea |
| InChI | InChI=1S/C27H23F2N7O3/c1-27(2,3)21-13-22(36(35-21)16-6-4-5-15(28)11-16)33-26(38)32-19-8-7-17(12-18(19)29)39-20-9-10-30-25-24(20)31-14-23(37)34-25/h4-14H,1-3H3,(H,30,34,37)(H2,32,33,38) |
| InChIKey | AJFKKXIBHCRFJO-UHFFFAOYSA-N |
| SMILES | CC(C)(C)C1=NN(C(=C1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C(=NC=C3)NC(=O)C=N4)F)C5=CC(=CC=C5)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
