TBAF Trihydrate

• CAT Number: R035221
• CAS Number: 87749-50-6
• Molecular Formula: C16H42FNO3
• Molecular Weight: 315.51
• Purity: ≥95%
• Synonyms: N,N,N-Tributyl-1-Butanaminium Fluoride trihydrate; Tetrabutylammonium Fluoride Trihydrate; TBAF.3H2O
• Storage: Room temperature
• IUPAC Name: tetrabutylazanium;fluoride;trihydrate
• InChI: InChI=1S/C16H36N.FH.3H2O/c1-5-9-13-17(14-10-6-2,15-11-7-3)16-12-8-4;;;;/h5-16H2,1-4H3;1H;3*1H2/q+1;;;;/p-1
• InChIKey: VEPTXBCIDSFGBF-UHFFFAOYSA-M
• SMILES: CCCC[N+](CCCC)(CCCC)CCCC.O.O.O.[F-]

Tetrabutylammonium fluoride trihydrate (Cat No.: R035221) is a quaternary ammonium salt widely used as a fluoride ion source in organic synthesis. It serves as an effective reagent for desilylation reactions, particularly for removing silyl protecting groups such as TBDMS and TMS from alcohols and amines. The trihydrate form provides enhanced stability and easier handling compared to anhydrous TBAF. Its nucleophilic fluoride ion also participates in various fluorination and deprotection reactions. TBAF trihydrate is intended strictly for laboratory research use.