Taurolithocholic acid sodium salt

• CAT Number: R010567
• CAS Number: 6042-32-6
• Molecular Formula: C26H44NNaO5S
• Molecular Weight: 505.69
• Purity: ≥95%
• Synonyms: sodium;2-[[(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonate
• InChI: InChI=1S/C26H45NO5S.Na/c1-17(4-9-24(29)27-14-15-33(30,31)32)21-7-8-22-20-6-5-18-16-19(28)10-12-25(18,2)23(20)11-13-26(21,22)3;/h17-23,28H,4-16H2,1-3H3,(H,27,29)(H,30,31,32);/q;+1/p-1/t17-,18-,19-,20+,21-,22+,23+,25+,26-;/m1./s1
• InChIKey: YAERYJYXPRIDTO-HRHHVWJRSA-M
• SMILES: CC(CCC(=O)NCCS(=O)(=O)[O-])C1CCC2C1(CCC3C2CCC4C3(CCC(C4)O)C)C.[Na+]

Taurolithocholic acid sodium salt (Cat No.: R010567) is a taurine-conjugated bile acid derived from lithocholic acid. It plays an important role in bile acid metabolism, cholesterol regulation, and lipid digestion. TLCA-Na is a potent activator of the G-protein–coupled bile acid receptor TGR5 and also influences farnesoid X receptor (FXR) signaling. In research, it is widely used to study bile acid–mediated signaling pathways, gut–liver axis communication, and metabolic regulation. TLCA-Na serves as a valuable tool in hepatology, gastroenterology, and metabolic disease research.

Reference

[1]. U Beuers, et al. Modulation of protein kinase C by taurolithocholic acid in isolated rat hepatocytes. Hepatology. 1999 Feb;29(2):477-82.
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[2]. Ulrich Beuers, et al. Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol 3-kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets. J Biol Chem. 2003 May 16;278(20):17810-8.
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