TAT-amide

• CAT Number: I017277
• CAS Number: 697226-52-1
• Molecular Formula: C64H119N33O13
• Molecular Weight: 1558.84
• Purity: ≥95%
• IUPAC Name: (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-N-[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pentanediamide
• InChI: InChI=1S/C64H119N33O13/c65-25-3-1-11-40(91-51(103)39(14-6-28-83-60(72)73)89-48(100)34-88-50(102)37(67)33-35-19-21-36(98)22-20-35)53(105)92-41(12-2-4-26-66)54(106)94-43(16-8-30-85-62(76)77)55(107)95-45(18-10-32-87-64(80)81)57(109)97-46(23-24-47(68)99)58(110)96-44(17-9-31-86-63(78)79)56(108)93-42(15-7-29-84-61(74)75)52(104)90-38(49(69)101)13-5-27-82-59(70)71/h19-22,37-46,98H,1-18,23-34,65-67H2,(H2,68,99)(H2,69,101)(H,88,102)(H,89,100)(H,90,104)(H,91,103)(H,92,105)(H,93,108)(H,94,106)(H,95,107)(H,96,110)(H,97,109)(H4,70,71,82)(H4,72,73,83)(H4,74,75,84)(H4,76,77,85)(H4,78,79,86)(H4,80,81,87)/t37-,38-,39-,40-,41-,42-,43-,44-,45-,46-/m0/s1
• InChIKey: FHNRCIMBMGTCBF-AGVBWZICSA-N
• SMILES: C1=CC(=CC=C1C[C@@H](C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N)N)O

TAT-amide(CAT: I017277) is a cell-penetrating peptide derived from the HIV-1 TAT protein, widely used as a delivery tool in biomedical research. Its sequence features an arginine- and lysine-rich domain that enables efficient transport of bioactive molecules, such as proteins, nucleic acids, and nanoparticles, across cellular membranes. The amide modification enhances its stability and reduces enzymatic degradation, making it highly effective in in vitro and in vivo applications. TAT-amide serves as a valuable carrier for drug delivery, gene therapy, and molecular imaging studies, helping researchers overcome cellular barriers and improve the intracellular uptake of therapeutic agents in diverse disease models.