TASP0415914

• CAT Number: I045538
• CAS Number: 1292300-75-4
• Molecular Formula: C13H17N5O3S
• Molecular Weight: 323.37
• Purity: ≥95%
• Synonyms: N-[5-[3-(3-hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl]-4-methyl-1,3-thiazol-2-yl]acetamide
• InChI: InChI=1S/C13H17N5O3S/c1-7-10(22-13(14-7)15-8(2)19)11-16-12(17-21-11)18-5-3-4-9(20)6-18/h9,20H,3-6H2,1-2H3,(H,14,15,19)
• InChIKey: WFQFHKQIDOCQTL-UHFFFAOYSA-N
• SMILES: CC1=C(SC(=N1)NC(=O)C)C2=NC(=NO2)N3CCCC(C3)O

TASP0415914 (Cat No.: I045538) is a selective small-molecule inhibitor of serine racemase (SRR), the enzyme that converts L-serine to D-serine, a key co-agonist of NMDA receptors in the brain. By lowering D-serine levels, TASP0415914 modulates NMDA receptor–mediated neurotransmission, offering potential therapeutic benefit in conditions associated with glutamatergic overactivation, such as schizophrenia, neuropathic pain, and neurodegenerative diseases. Preclinical studies highlight its ability to reduce excitotoxicity and abnormal signaling. As such, TASP0415914 serves as a promising tool for neurological and psychiatric research.

Reference

[1]. Yusuke Oka, et al. Discovery of N-{5-[3-(3-hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl]-4-methyl-1,3-thiazol-2-yl}acetamide (TASP0415914) as an orally potent phosphoinositide 3-kinase γ inhibitor for the treatment of inflammatory diseases. Bioorg Med Chem
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