For research use only. Not for therapeutic Use.
TASP0390325 (Cat No.: I011284) is a potent, selective small-molecule RORγt (retinoic acid receptor-related orphan receptor gamma t) antagonist developed for research in immunology and inflammatory diseases. By blocking RORγt activity, it suppresses differentiation and function of Th17 cells, reducing production of pro-inflammatory cytokines such as IL-17. TASP0390325 has been investigated for potential therapeutic applications in autoimmune disorders including psoriasis, rheumatoid arthritis, and inflammatory bowel disease. It serves as a valuable tool for studying nuclear receptor signaling, immune regulation, and drug discovery in immunology.
| CAS Number | 1642187-96-9 |
| Synonyms | 2-[2-(3-chloro-4-fluorophenyl)-6-(3-morpholin-4-ylpropoxy)-4-oxopyrido[2,3-d]pyrimidin-3-yl]-N-propan-2-ylacetamide;hydrochloride |
| Molecular Formula | C25H30Cl2FN5O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C25H29ClFN5O4.ClH/c1-16(2)29-22(33)15-32-24(17-4-5-21(27)20(26)12-17)30-23-19(25(32)34)13-18(14-28-23)36-9-3-6-31-7-10-35-11-8-31;/h4-5,12-14,16H,3,6-11,15H2,1-2H3,(H,29,33);1H |
| InChIKey | NUIXGNLBPARAII-UHFFFAOYSA-N |
| SMILES | CC(C)NC(=O)CN1C(=NC2=C(C1=O)C=C(C=N2)OCCCN3CCOCC3)C4=CC(=C(C=C4)F)Cl.Cl |
| Reference | [1]. M Iijima, et al. Antidepressant and anxiolytic profiles of newly synthesized arginine vasopressin V1B receptor antagonists: TASP0233278 and TASP0390325. Br J Pharmacol. 2014 Jul;171(14):3511-25. [2]. Kazumi Koga, et al. High-Contrast PET Imaging of Vasopressin V 1B Receptors with a Novel Radioligand, 11C-TASP699. J Nucl Med. 2017 Oct;58(10):1652-1658. |
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