TASK-1-IN-1

• CAT Number: I042462
• CAS Number: 600125-11-9
• Molecular Formula: C22H20N2O2
• Molecular Weight: 344.41
• Purity: ≥95%
• Synonyms: 3-benzamido-N-(2-ethylphenyl)benzamide
• InChI: InChI=1S/C22H20N2O2/c1-2-16-9-6-7-14-20(16)24-22(26)18-12-8-13-19(15-18)23-21(25)17-10-4-3-5-11-17/h3-15H,2H2,1H3,(H,23,25)(H,24,26)
• InChIKey: MRIKKSSTVCDDDZ-UHFFFAOYSA-N
• SMILES: CCC1=CC=CC=C1NC(=O)C2=CC(=CC=C2)NC(=O)C3=CC=CC=C3

TASK-1-IN-1 (Cat No.: I042462) is a selective inhibitor of the TASK-1 (TWIK-related acid-sensitive potassium channel 1), a member of the two-pore domain potassium (K2P) channel family involved in regulating resting membrane potential and cellular excitability. By blocking TASK-1 activity, this compound modulates neuronal and cardiac excitability, making it a valuable tool in research on sleep apnea, atrial fibrillation, and pulmonary arterial hypertension. TASK-1-IN-1 supports the exploration of ion channel pharmacology and the development of therapies targeting K2P channel–related disorders.

Reference

[1]. Bárbara Arévalo, et al. Selective TASK-1 Inhibitor with a Defined Structure-Activity Relationship Reduces Cancer Cell Proliferation and Viability. J Med Chem. 2022 Nov 24;65(22):15014-15027.
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