For research use only. Not for therapeutic Use.
TASIN-1 (Cat No.:R066910) is a selective inhibitor specifically targeting cancer cells harboring truncated adenomatous polyposis coli (APC) mutations, common in colorectal cancers. By selectively inducing apoptosis in APC-mutant cells, TASIN-1 spares healthy cells, significantly reducing off-target cytotoxicity. This specificity stems from its modulation of cholesterol biosynthesis, a vulnerability uniquely pronounced in truncated APC-driven tumors. TASIN-1 represents a valuable research tool for understanding APC-related carcinogenesis, identifying therapeutic targets within cholesterol metabolic pathways, and developing precision treatments against colorectal cancer driven by APC gene mutations.
| CAS Number | 792927-06-1 |
| Synonyms | 1-[1-(4-methoxyphenyl)sulfonylpiperidin-4-yl]-4-methylpiperidine |
| Molecular Formula | C18H28N2O3S |
| Purity | ≥95% |
| IUPAC Name | 1-[1-(4-methoxyphenyl)sulfonylpiperidin-4-yl]-4-methylpiperidine |
| InChI | InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)16-9-13-20(14-10-16)24(21,22)18-5-3-17(23-2)4-6-18/h3-6,15-16H,7-14H2,1-2H3 |
| InChIKey | XCBHYDPDIJQQGM-UHFFFAOYSA-N |
| SMILES | CC1CCN(CC1)C2CCN(CC2)S(=O)(=O)C3=CC=C(C=C3)OC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
