Tanshindiol C

• CAT Number: I042500
• CAS Number: 97465-71-9
• Molecular Formula: C18H16O5
• Molecular Weight: 312.32
• Purity: ≥95%
• Synonyms: (6R,7R)-6,7-dihydroxy-1,6-dimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-10,11-dione
• InChI: InChI=1S/C18H16O5/c1-8-7-23-17-10-3-5-11-9(4-6-12(19)18(11,2)22)14(10)16(21)15(20)13(8)17/h3,5,7,12,19,22H,4,6H2,1-2H3/t12-,18-/m1/s1
• InChIKey: RTKDBIDPGKCZJS-KZULUSFZSA-N
• SMILES: CC1=COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCC(C4(C)O)O

Tanshindiol C (Cat No.: I042500) is a bioactive diterpenoid compound isolated from Salvia miltiorrhiza (Danshen), a traditional Chinese medicinal herb. Known for its antioxidant and anti-inflammatory properties, Tanshindiol C has shown potential in cardiovascular protection by inhibiting lipid peroxidation and improving endothelial function. It also exhibits anticancer and neuroprotective effects in preclinical studies. As a natural compound, it is used in research exploring therapeutic applications in ischemic diseases, atherosclerosis, and oxidative stress–related disorders, contributing to the pharmacological understanding of Danshen-derived constituents.

Reference

[1]. Yuyu Yang, et al. Tanshindiol C inhibits oxidized low-density lipoprotein induced macrophage foam cell formation via a peroxiredoxin 1 dependent pathway. Biochim Biophys Acta Mol Basis Dis. 2018 Mar;1864(3):882-890.
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[2]. Jimin Woo, et al. Biological evaluation of tanshindiols as EZH2 histone methyltransferase inhibitors. Bioorg Med Chem Lett. 2014 Jun 1;24(11):2486-92.
[Content Brief]