TAMRA azide, 5-isomer

• CAT Number: I042568
• CAS Number: 825651-66-9
• Molecular Formula: C28H28N6O4
• Molecular Weight: 512.56
• Purity: ≥95%
• Synonyms: 5-(3-azidopropylcarbamoyl)-2-[3-(dimethylamino)-6-dimethylazaniumylidenexanthen-9-yl]benzoate
• InChI: InChI=1S/C28H28N6O4/c1-33(2)18-7-10-21-24(15-18)38-25-16-19(34(3)4)8-11-22(25)26(21)20-9-6-17(14-23(20)28(36)37)27(35)30-12-5-13-31-32-29/h6-11,14-16H,5,12-13H2,1-4H3,(H-,30,35,36,37)
• InChIKey: XASWYZOPZJEQFF-UHFFFAOYSA-N
• SMILES: CN(C)C1=CC2=C(C=C1)C(=C3C=CC(=[N+](C)C)C=C3O2)C4=C(C=C(C=C4)C(=O)NCCCN=[N+]=[N-])C(=O)[O-]

TAMRA azide, 5-isomer (Cat No.: I042568) is a red-fluorescent dye derivative of tetramethylrhodamine (TAMRA), modified with an azide group at the 5-position. This azide functionality enables highly specific conjugation to alkyne-containing molecules through click chemistry, particularly copper-catalyzed azide-alkyne cycloaddition (CuAAC). It is commonly used for fluorescent labeling of biomolecules, including peptides, proteins, and nucleic acids, in imaging and detection assays. With strong fluorescence, excellent photostability, and compatibility with various bioorthogonal applications, TAMRA azide, 5-isomer is a versatile tool in molecular and cellular biology research.

Reference

[1]. Willnow S, et al. A selenium-based click AdoMet analogue for versatile substrate labeling with wild-type protein methyltransferases. Chembiochem. 2012 May 29;13(8):1167-73.
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[2]. Jiang X, et al. Recent applications of click chemistry in drug discovery. Expert Opin Drug Discov. 2019 Aug;14(8):779-789.
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