Taltobulin intermediate-4

• CAT Number: I040498
• CAS Number: 187345-37-5
• Molecular Formula: C22H40N2O5
• Molecular Weight: 412.56
• Purity: ≥95%
• Synonyms: ethyl (E,4S)-4-[[(2S)-3,3-dimethyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoyl]-methylamino]-2,5-dimethylhex-2-enoate
• InChI: InChI=1S/C22H40N2O5/c1-12-28-19(26)15(4)13-16(14(2)3)24(11)18(25)17(21(5,6)7)23-20(27)29-22(8,9)10/h13-14,16-17H,12H2,1-11H3,(H,23,27)/b15-13+/t16-,17-/m1/s1
• InChIKey: MFZVQAHFZVUOFQ-IDGBWPAGSA-N
• SMILES: CCOC(=O)C(=CC(C(C)C)N(C)C(=O)C(C(C)(C)C)NC(=O)OC(C)(C)C)C

Taltobulin Intermediate-4(CAT: I040498) is a key synthetic precursor in the production of Taltobulin (HY-15584), a potent microtubule-targeting agent widely used as a cytotoxic payload in antibody-drug conjugates (ADCs). This intermediate plays a critical role in assembling the final active compound, which functions by inhibiting tubulin polymerization, thereby inducing mitotic arrest and promoting apoptosis in rapidly dividing cancer cells. Taltobulin Intermediate-4 is ideal for researchers involved in ADC development, medicinal chemistry, and the design of targeted chemotherapeutic agents. Supplied in high purity, it supports efficient and scalable synthesis of Taltobulin-based drug conjugates for preclinical oncology research.