For research use only. Not for therapeutic Use.
Talazoparib-¹³C,d₄(CAT: I040265) is a stable isotope-labeled analog of Talazoparib (HY-16106), incorporating four deuterium (²H) atoms and one carbon-13 (¹³C) atom. Talazoparib is a potent, orally active PARP1/2 inhibitor with K<sub>i</sub> values of 1.2 nM and 0.87 nM, respectively, and exhibits strong anti-tumor activity through the inhibition of DNA repair in cancer cells. The labeled version is ideal for use in pharmacokinetic, metabolic, and bioanalytical studies, serving as a quantitative tracer in drug development workflows. Deuteration may also influence the compound’s metabolic stability.
| Synonyms | (11S,12R)-7-fluoro-12-(2-methyl-1,2,4-triazol-3-yl)-11-(2,3,5,6-tetradeuterio-4-fluorophenyl)-2,3,10-triazatricyclo[7.3.1.05,13]trideca-1,5(13),6,8-tetraen-4-one |
| Molecular Formula | C1813CH10D4F2N6O |
| Purity | ≥95% |
| IUPAC Name | (11S,12R)-7-fluoro-12-(2-methyl-1,2,4-triazol-3-yl)-11-(2,3,5,6-tetradeuterio-4-fluorophenyl)-2,3,10-triazatricyclo[7.3.1.05,13]trideca-1,5(13),6,8-tetraen-4-one |
| InChI | InChI=1S/C19H14F2N6O/c1-27-18(22-8-23-27)15-16(9-2-4-10(20)5-3-9)24-13-7-11(21)6-12-14(13)17(15)25-26-19(12)28/h2-8,15-16,24H,1H3,(H,26,28)/t15-,16-/m1/s1/i2D,3D,4D,5D,16+1 |
| InChIKey | HWGQMRYQVZSGDQ-UWQIOMAISA-N |
| SMILES | CN1C(=NC=N1)C2C(NC3=CC(=CC4=C3C2=NNC4=O)F)C5=CC=C(C=C5)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
