TAK1-IN-2

• CAT Number: I045402
• CAS Number: 2763213-98-3
• Molecular Formula: C26H26F2N6O5
• Molecular Weight: 540.52
• Purity: ≥95%
• Synonyms: 2-[5-[[2-(difluoromethoxy)phenyl]methyl-[(2R)-1-(methylamino)-1-oxopropan-2-yl]carbamoyl]-1H-imidazole-2-carbonyl]-1,3-dihydroisoindole-5-carboxamide
• InChI: InChI=1S/C26H26F2N6O5/c1-14(23(36)30-2)34(13-17-5-3-4-6-20(17)39-26(27)28)24(37)19-10-31-22(32-19)25(38)33-11-16-8-7-15(21(29)35)9-18(16)12-33/h3-10,14,26H,11-13H2,1-2H3,(H2,29,35)(H,30,36)(H,31,32)/t14-/m1/s1
• InChIKey: QEAYKBGEHPZBIL-CQSZACIVSA-N
• SMILES: CC(C(=O)NC)N(CC1=CC=CC=C1OC(F)F)C(=O)C2=CN=C(N2)C(=O)N3CC4=C(C3)C=C(C=C4)C(=O)N

TAK1-IN-2 (Cat No.: I045402) is a selective inhibitor of Transforming Growth Factor-β-Activated Kinase 1 (TAK1), a key regulator in the MAPK and NF-κB signaling pathways. TAK1 plays a central role in inflammatory responses, apoptosis, and cell survival, especially in cancer and autoimmune diseases. By inhibiting TAK1 activity, TAK1-IN-2 suppresses proinflammatory cytokine production and sensitizes tumor cells to apoptosis. It is widely used in preclinical research to explore TAK1-dependent mechanisms in oncology, inflammation, and innate immune signaling.

Reference

[1]. Veerman JJN, et, al. Discovery of 2,4-1 H-Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors. ACS Med Chem Lett. 2021 Mar 3;12(4):555-562.
[Content Brief]