For research use only. Not for therapeutic Use.
TAK-615（Cat No.:I015019）is a potent and selective inhibitor of receptor-interacting protein kinase 1 (RIPK1), a key mediator of necroptosis, inflammation, and cell death. By blocking RIPK1 signaling, TAK-615 prevents necroptotic cell death and reduces the release of pro-inflammatory cytokines, making it a valuable pharmacological tool in studying programmed necrosis and immune regulation. It has been investigated in preclinical models of inflammatory and neurodegenerative diseases, including multiple sclerosis and ischemic injury. TAK-615 supports therapeutic exploration of RIPK1 inhibition for treating disorders driven by aberrant cell death and inflammation.
| CAS Number | 1664335-55-0 |
| Synonyms | 4-[[cyclopropylmethyl-[4-(2-fluorophenoxy)benzoyl]amino]methyl]benzoic acid |
| Molecular Formula | C25H22FNO4 |
| Purity | ≥95% |
| IUPAC Name | 4-[[cyclopropylmethyl-[4-(2-fluorophenoxy)benzoyl]amino]methyl]benzoic acid |
| InChI | InChI=1S/C25H22FNO4/c26-22-3-1-2-4-23(22)31-21-13-11-19(12-14-21)24(28)27(15-17-5-6-17)16-18-7-9-20(10-8-18)25(29)30/h1-4,7-14,17H,5-6,15-16H2,(H,29,30) |
| InChIKey | LEZVXIZCJXKBJY-UHFFFAOYSA-N |
| SMILES | C1CC1CN(CC2=CC=C(C=C2)C(=O)O)C(=O)C3=CC=C(C=C3)OC4=CC=CC=C4F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
