For research use only. Not for therapeutic Use.
TAK-418（Cat No.:I036962）is a selective small-molecule inhibitor of lysine-specific demethylase 1A (KDM1A or LSD1), an epigenetic regulator that removes methyl groups from histone H3 lysine 4 (H3K4), thereby repressing gene expression. By inhibiting LSD1, TAK-418 promotes chromatin remodeling and the reactivation of genes involved in neurodevelopment and synaptic function. It has shown potential in preclinical and early clinical studies for treating cognitive and behavioral deficits, particularly in neurodevelopmental disorders such as Kabuki syndrome. TAK-418 is a promising therapeutic candidate for modulating epigenetic dysregulation in neurological and psychiatric conditions.
| CAS Number | 1818252-53-7 |
| Synonyms | 5-[(1R,2R)-2-(cyclopropylmethylamino)cyclopropyl]-N-(oxan-4-yl)thiophene-3-carboxamide;hydrochloride |
| Molecular Formula | C17H25ClN2O2S |
| Purity | ≥95% |
| IUPAC Name | 5-[(1R,2R)-2-(cyclopropylmethylamino)cyclopropyl]-N-(oxan-4-yl)thiophene-3-carboxamide;hydrochloride |
| InChI | InChI=1S/C17H24N2O2S.ClH/c20-17(19-13-3-5-21-6-4-13)12-7-16(22-10-12)14-8-15(14)18-9-11-1-2-11;/h7,10-11,13-15,18H,1-6,8-9H2,(H,19,20);1H/t14-,15-;/m1./s1 |
| InChIKey | LEEWMGOHGNRDKC-CTHHTMFSSA-N |
| SMILES | C1CC1CN[C@@H]2C[C@H]2C3=CC(=CS3)C(=O)NC4CCOCC4.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
