For research use only. Not for therapeutic Use.
Taccalonolide C（Cat No.:I044885）is a highly oxygenated pentacyclic steroidal compound isolated from plants of the Tacca genus, particularly Tacca chantrieri. It belongs to the taccalonolide class of microtubule-stabilizing agents, which exhibit potent antitumor activity. Unlike taxanes, Taccalonolide C binds covalently to tubulin, promoting microtubule polymerization and disrupting cell division. This unique mechanism allows it to overcome drug resistance in cancer cells. It has shown promising effects in preclinical models of breast and ovarian cancers. Taccalonolide C is a valuable lead compound in anticancer drug development and natural product pharmacology.
| CAS Number | 117803-96-0 |
| Synonyms | [(1R,2S,3S,4R,6S,8S,10S,11R,12R,13S,14S,15R,16R,17S,18R,21S,22S,25R)-4,11,15-triacetyloxy-22-hydroxy-12,16,18,21,22-pentamethyl-5,20,23-trioxo-9,24-dioxaheptacyclo[15.7.1.02,16.03,13.06,12.08,10.021,25]pentacosan-14-yl] acetate |
| Molecular Formula | C36H46O14 |
| Purity | ≥95% |
| IUPAC Name | [(1R,2S,3S,4R,6S,8S,10S,11R,12R,13S,14S,15R,16R,17S,18R,21S,22S,25R)-4,11,15-triacetyloxy-22-hydroxy-12,16,18,21,22-pentamethyl-5,20,23-trioxo-9,24-dioxaheptacyclo[15.7.1.02,16.03,13.06,12.08,10.021,25]pentacosan-14-yl] acetate |
| InChI | InChI=1S/C36H46O14/c1-12-10-19(41)35(8)24-21(12)34(7)22(28(24)50-32(43)36(35,9)44)20-23(29(46-14(3)38)31(34)48-16(5)40)33(6)17(25(42)27(20)45-13(2)37)11-18-26(49-18)30(33)47-15(4)39/h12,17-18,20-24,26-31,44H,10-11H2,1-9H3/t12-,17-,18+,20+,21+,22-,23-,24+,26+,27-,28-,29+,30+,31+,33+,34-,35+,36-/m1/s1 |
| InChIKey | RXQVUONAHNHYNF-XSUQWDDVSA-N |
| SMILES | C[C@@H]1CC(=O)[C@]2([C@H]3[C@H]1[C@@]4([C@@H]([C@H]3OC(=O)[C@@]2(C)O)[C@H]5[C@H]([C@@H]([C@@H]4OC(=O)C)OC(=O)C)[C@@]6([C@H](C[C@H]7[C@@H]([C@@H]6OC(=O)C)O7)C(=O)[C@@H]5OC(=O)C)C)C)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
