T3Inh-1

• CAT Number: I044348
• CAS Number: 50440-30-7
• Molecular Formula: C27H20N6O3
• Molecular Weight: 476.49
• Purity: ≥95%
• Synonyms: 4-[(6-nitroquinolin-4-yl)amino]-N-[4-(pyridin-4-ylamino)phenyl]benzamide
• InChI: InChI=1S/C27H20N6O3/c34-27(32-21-7-5-19(6-8-21)30-22-11-14-28-15-12-22)18-1-3-20(4-2-18)31-26-13-16-29-25-10-9-23(33(35)36)17-24(25)26/h1-17H,(H,28,30)(H,29,31)(H,32,34)
• InChIKey: KUBNLSZSAIOAMS-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1C(=O)NC2=CC=C(C=C2)NC3=CC=NC=C3)NC4=C5C=C(C=CC5=NC=C4)[N+](=O)[O-]

T3Inh-1（Cat No.:I044348）is a selective small-molecule inhibitor targeting the TGFβ type III receptor (TβRIII or betaglycan), a co-receptor involved in modulating TGFβ signaling pathways. By blocking TβRIII-mediated interactions, T3Inh-1 interferes with TGFβ ligand binding and downstream signaling, which are often dysregulated in cancer, fibrosis, and immune disorders. T3Inh-1 has demonstrated potential in reducing tumor cell invasiveness and epithelial-to-mesenchymal transition (EMT), processes driven by aberrant TGFβ activity. As a novel modulator of TGFβ signaling, T3Inh-1 offers a promising approach for targeting TβRIII-associated pathologies and exploring new therapeutic strategies.