Syringaresinol

• CAT Number: I012190
• CAS Number: 487-35-4
• Molecular Formula: C22H26O8
• Molecular Weight: 418.44
• Purity: ≥95%
• Synonyms: 4-[6-(4-hydroxy-3,5-dimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2,6-dimethoxyphenol
• InChI: InChI=1S/C22H26O8/c1-25-15-5-11(6-16(26-2)19(15)23)21-13-9-30-22(14(13)10-29-21)12-7-17(27-3)20(24)18(8-12)28-4/h5-8,13-14,21-24H,9-10H2,1-4H3
• InChIKey: KOWMJRJXZMEZLD-UHFFFAOYSA-N
• SMILES: COC1=CC(=CC(=C1O)OC)C2C3COC(C3CO2)C4=CC(=C(C(=C4)OC)O)OC

Syringaresinol (Cat No.: I012190) is a naturally occurring lignan found in various plants, including Eleutherococcus senticosus and Magnolia fargesii. It exhibits a range of bioactivities, including antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. Syringaresinol functions by modulating signaling pathways such as NF-κB and MAPK, contributing to its therapeutic potential in oxidative stress–related disorders, cardiovascular diseases, and neurodegeneration. It also shows estrogenic and anti-estrogenic activities, making it relevant in hormone-related research. Syringaresinol is widely studied in natural product chemistry and pharmacological development.

Reference

[1]. YingLUO, et al. Chemical Constituents from Dragon’s Blood of Dracaena cambodiana. Chinese Journal of Natural Medicines, Volume 9, Issue 2, March 2011, Pages 112-114.

[2]. Chung BH, et al. Syringaresinol causes vasorelaxation by elevating nitric oxide production through the phosphorylation and dimerization of endothelial nitric oxide synthase. Exp Mol Med. 2012 Mar 31;44(3):191-201.
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