Synephrine

• CAT Number: R006478
• CAS Number: 94-07-5
• Molecular Formula: C9H13NO2
• Molecular Weight: 167.21
• Purity: ≥95%
• Synonyms: 4-[1-hydroxy-2-(methylamino)ethyl]phenol
• InChI: InChI=1S/C9H13NO2/c1-10-6-9(12)7-2-4-8(11)5-3-7/h2-5,9-12H,6H2,1H3
• InChIKey: YRCWQPVGYLYSOX-UHFFFAOYSA-N
• SMILES: CNCC(C1=CC=C(C=C1)O)O

Synephrine (Cat No.: R006478) is a naturally occurring alkaloid found primarily in bitter orange (Citrus aurantium) and other citrus species. Structurally similar to epinephrine and phenylephrine, it acts as a sympathomimetic agent, primarily stimulating adrenergic receptors. Synephrine is commonly used in dietary supplements for weight loss and energy enhancement due to its thermogenic and appetite-suppressing effects. It exists in several isomeric forms, with p-synephrine being the most biologically active. Its cardiovascular effects have raised concerns, prompting regulatory scrutiny in some countries.

Reference

[1]. Thomas JE, et al. STEMI in a 24-year-old man after use of a synephrine-containing dietary supplement: a case report and review of the literature. Tex Heart Inst J. 2009;36(6):586-90.
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[2]. Huang YT, et al. Hemodynamic effects of synephrine treatment in portal hypertensive rats. Jpn J Pharmacol. 2001 Feb;85(2):183-8.
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