For research use only. Not for therapeutic Use.
SWTX-143(CAT: I040583) is a novel, covalent inhibitor of the YAP/TAZ–TEAD transcriptional complex, selectively binding to the conserved palmitoylation pocket across all four TEAD isoforms (TEAD1–4). By covalently modifying this site, SWTX-143 irreversibly disrupts TEAD palmitoylation and blocks YAP/TAZ-driven transcriptional activity—key drivers of tumor growth and survival. This compound demonstrates high specificity, sustained inhibition, and potent antitumor activity in preclinical cancer models. SWTX-143 is a valuable tool for studying Hippo pathway signaling and its role in oncogenesis, and it offers strong therapeutic potential for targeting TEAD-dependent cancers with aberrant YAP/TAZ activation.
| CAS Number | 2766575-48-6 |
| Synonyms | N-[5-amino-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-2H-quinolin-3-yl]prop-2-enamide |
| Molecular Formula | C19H18F3N3O |
| Purity | ≥95% |
| IUPAC Name | N-[5-amino-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-2H-quinolin-3-yl]prop-2-enamide |
| InChI | InChI=1S/C19H18F3N3O/c1-2-18(26)24-13-10-15-16(23)4-3-5-17(15)25(11-13)14-8-6-12(7-9-14)19(20,21)22/h2-9,13H,1,10-11,23H2,(H,24,26) |
| InChIKey | YZNSUDZUJLMKNI-UHFFFAOYSA-N |
| SMILES | C=CC(=O)NC1CC2=C(C=CC=C2N(C1)C3=CC=C(C=C3)C(F)(F)F)N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
