Sulazepam is a benzodiazepine derivative. It is the thioamide derivative of diazepam. It is metabolised into diazepam, desmethyldiazepam and oxydiazepam. It has sedative, muscle relaxant, hypnotic, anticonvulsant and anxiolytic properties like those of other benzodiazepines. It was never marketed. Sulazepam is not available (potentially a controlled substance).
| Catalog Number | I036770 |
| CAS Number | 2898-13-7 |
| Synonyms | Sulazepam; W 3676; W-3676; W3676. |
| Molecular Formula | C16H13ClN2S |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 2H-1,4-Benzodiazepine-2-thione, 7-chloro-1,3-dihydro-1-methyl-5-phenyl- |
| InChI | InChI=1S/C16H13ClN2S/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3 |
| InChIKey | MWGWTOPCKLQYEU-UHFFFAOYSA-N |
| SMILES | S=C1N(C)C2=CC=C(Cl)C=C2C(C3=CC=CC=C3)=NC1 |
| Reference | 1: Pera T, Deshpande DA, Ippolito M, Wang B, Gavrila A, Michael JV, Nayak AP, Tompkins E, Farrell E, Kroeze WK, Roth BL, Panettieri RA Jr., Benovic JL, An SS, Dulin NO, Penn RB. Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines. FASEB J. 2018 Feb;32(2):862-874. doi: 10.1096/fj.201700555R. Epub 2018 Jan 4. PubMed PMID: 29042451; PubMed Central PMCID: PMC5888400. |
