SU4984

• CAT Number: M130953
• CAS Number: 186610-89-9
• Molecular Formula: C20H19N3O2
• Molecular Weight: 333.38
• Purity: ≥95%
• Synonyms: 4-[4-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]phenyl]piperazine-1-carbaldehyde
• InChI: InChI=1S/C20H19N3O2/c24-14-22-9-11-23(12-10-22)16-7-5-15(6-8-16)13-18-17-3-1-2-4-19(17)21-20(18)25/h1-8,13-14H,9-12H2,(H,21,25)/b18-13-
• InChIKey: ZNFJBJDODKHWED-AQTBWJFISA-N
• SMILES: C1CN(CCN1C=O)C2=CC=C(C=C2)C=C3C4=CC=CC=C4NC3=O

SU4984 (Cat No.: M130953) is a synthetic small-molecule tyrosine kinase inhibitor structurally related to SU5416 and SU11248. It selectively targets receptor tyrosine kinases such as VEGFR, PDGFR, and FGFR, disrupting signaling pathways essential for angiogenesis, cell proliferation, and survival. SU4984 has been widely used in research to study tumor growth, vascular biology, and kinase-driven signaling mechanisms. Although not developed as a therapeutic, it serves as a valuable chemical probe in oncology, angiogenesis research, and drug discovery focused on receptor tyrosine kinases.

Reference

[1]. Mohammadi M, et, al. Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science. 1997 May 9;276(5314):955-60.
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[2]. Ma Y, et, al. Indolinone derivatives inhibit constitutively activated KIT mutants and kill neoplastic mast cells. J Invest Dermatol. 2000 Feb;114(2):392-4.
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