Strictosamide

  • CAT Number: R024101
  • CAS Number: 23141-25-5
  • Molecular Formula: C26H30N2O8
  • Molecular Weight: 498.532
  • Purity: ≥95%
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<span style="color:#000000;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:12px;">Strictosamide (CAS&nbsp;23141-25-5)&nbsp;<span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">possesses antibacterial and antiviral activities with important effects on inflammation and inflammatory pain. Strictosamide is slightly toxic to Charles River mouse (LD(50)=723.17 mg/kg), producing CNS depression and kidney toxicity. Strictosamide has nonsignificant in vitro and in vivo effect on kidney Na(+),K(+)-ATPase activity but produced an in vivo increase of Na(+),K(+)-ATPase activity of brain.</span></span></span></span>

Catalog Number R024101
CAS Number 23141-25-5
Molecular Formula

C26H30N2O8

Purity 95%
IUPAC Name (1S,18S,19R,20S)-19-ethenyl-18-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4,6,8,15-pentaen-14-one
InChI InChI=1S/C26H30N2O8/c1-2-12-15-9-18-20-14(13-5-3-4-6-17(13)27-20)7-8-28(18)24(33)16(15)11-34-25(12)36-26-23(32)22(31)21(30)19(10-29)35-26/h2-6,11-12,15,18-19,21-23,25-27,29-32H,1,7-10H2/t12-,15+,18+,19-,21-,22+,23-,25+,26+/m1/s1
InChIKey LBRPLJCNRZUXLS-IUNANRIWSA-N
SMILES C=CC1C2CC3C4=C(CCN3C(=O)C2=COC1OC5C(C(C(C(O5)CO)O)O)O)C6=CC=CC=C6N4
Reference

<span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:12px;">1.<span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">Li, Zan, et al. &quot;Synthesis and biological evaluation of strictosamide derivatives with improved antiviral and antiproliferative activities.&quot;&nbsp;</span><i style="font-family: Arial, sans-serif; font-size: 13px; font-variant-ligatures: normal; orphans: 2; widows: 2;">Chemical biology &amp; drug design</i><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">&nbsp;86.4 (2015): 523-530.<br />
2.</span><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">Zhenzhen, S. U., et al. &quot;Experimental Research on Effect of Strictosamide Injection on Cardiovascular System.&quot;&nbsp;</span><i style="font-family: Arial, sans-serif; font-size: 13px; font-variant-ligatures: normal; orphans: 2; widows: 2;">World Science and Technology-Modernization of Traditional Chinese Medicine</i><span style="font-variant-ligatures: normal; orphans: 2; widows: 2;">&nbsp;7 (2014): 1558-1564.</span></span></span>

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