Streptolysin O

• CAT Number: I017311
• CAS Number: 98072-47-0
• Purity: ≥95%

Streptolysin O (CAT: I017311) is a cholesterol-dependent, oxygen-labile cytolysin produced by Streptococcus pyogenes. It binds to cholesterol-containing membranes and forms pores, leading to cell lysis and cytotoxicity. Widely used in cell biology and immunology research, SLO enables selective plasma membrane permeabilization, allowing controlled delivery of macromolecules into the cytosol while preserving organelle integrity. It is also applied in studies of bacterial pathogenesis, host–pathogen interactions, and immune response mechanisms. Due to its reversible activity under reducing conditions, Streptolysin O serves as a versatile experimental tool in membrane biology, cytosolic delivery assays, and infection research.

Reference

[1]. Sierig G, et al. Cytotoxic effects of streptolysin o and streptolysin s enhance the virulence of poorlyencapsulated group a streptococci. Infect Immun. 2003 Jan;71(1):446-55.
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[2]. Van Epps DE, et al. Streptolysin O II. Relationship of Sulfyhdryl Groups to Activity. Infect Immun. 1971 May;3(5):648-52.
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[3]. Uchiyama S, et al. Streptolysin O Rapidly Impairs Neutrophil Oxidative Burst and Antibacterial Responses to Group A Streptococcus. Front Immunol. 2015 Nov 16;6:581.
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[4]. Yamamoto I, et al. Mutational and comparative analysis of streptolysin O, an oxygen-labile streptococcal hemolysin. Biosci Biotechnol Biochem. 2001 Dec;65(12):2682-9.
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