For research use only. Not for therapeutic Use.
STAT3-IN-15 (Cat No.: I042380) is a selective small-molecule inhibitor targeting STAT3 (Signal Transducer and Activator of Transcription 3), a transcription factor involved in cell growth, survival, inflammation, and immune regulation. By blocking STAT3 phosphorylation and dimerization, STAT3-IN-15 prevents its nuclear translocation and downstream gene expression. It is particularly useful in cancer research, where aberrant STAT3 signaling drives tumor proliferation, metastasis, and immune evasion. STAT3-IN-15 also aids in studying inflammatory and autoimmune diseases, offering potential for therapeutic development targeting dysregulated STAT3 signaling pathways.
| Synonyms | (1,1-dioxo-1-benzothiophen-2-yl)-[4-[(2,4,5-trifluorophenyl)methyl]piperazin-1-yl]methanone |
| Molecular Formula | C20H17F3N2O3S |
| Purity | ≥95% |
| InChI | InChI=1S/C20H17F3N2O3S/c21-15-11-17(23)16(22)9-14(15)12-24-5-7-25(8-6-24)20(26)19-10-13-3-1-2-4-18(13)29(19,27)28/h1-4,9-11H,5-8,12H2 |
| InChIKey | MSOPUAJZYRMAJX-UHFFFAOYSA-N |
| SMILES | C1CN(CCN1CC2=CC(=C(C=C2F)F)F)C(=O)C3=CC4=CC=CC=C4S3(=O)=O |
| Reference | [1]. Wang Y, et al. Discovery of the novel Benzo[b]thiophene 1,1-dioxide derivatives as a potent STAT3 inhibitor against idiopathic pulmonary fibrosis. Eur J Med Chem. 2022 Nov 28;246:114953. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
