SSTR5 antagonist 2 hydrochloride

• CAT Number: I045585
• CAS Number: 2988224-31-1
• Molecular Formula: C32H36ClFN2O5
• Molecular Weight: 583.09
• Purity: ≥95%
• Synonyms: 4-[8-[[3,5-diethoxy-4-(4-fluorophenyl)phenyl]methyl]-3-oxo-2,8-diazaspiro[4.5]decan-2-yl]benzoic acid;hydrochloride
• InChI: InChI=1S/C32H35FN2O5.ClH/c1-3-39-27-17-22(18-28(40-4-2)30(27)23-5-9-25(33)10-6-23)20-34-15-13-32(14-16-34)19-29(36)35(21-32)26-11-7-24(8-12-26)31(37)38;/h5-12,17-18H,3-4,13-16,19-21H2,1-2H3,(H,37,38);1H
• InChIKey: INOFULPPOPEZJZ-UHFFFAOYSA-N
• SMILES: CCOC1=CC(=CC(=C1C2=CC=C(C=C2)F)OCC)CN3CCC4(CC3)CC(=O)N(C4)C5=CC=C(C=C5)C(=O)O.Cl

SSTR5 antagonist 2 hydrochloride (Cat No.: I045585) is a selective small-molecule antagonist of the somatostatin receptor subtype 5 (SSTR5), a G-protein–coupled receptor involved in regulating hormone secretion, cell proliferation, and neurotransmission. By blocking SSTR5 signaling, this compound has been used to study somatostatin-mediated pathways in endocrinology, neurobiology, and cancer research. It provides a valuable pharmacological tool for dissecting receptor subtype specificity, exploring SSTR5’s role in pancreatic islet function, and evaluating therapeutic strategies targeting somatostatin receptors in metabolic and neuroendocrine disorders.

Reference

[1]. Liu W, et al. Discovery and Pharmacology of a Novel Somatostatin Subtype 5 (SSTR5) Antagonist: Synergy with DPP-4 Inhibition. ACS Med Chem Lett. 2018;9(11):1082-1087. Published 2018 Sep 12.
[Content Brief]