For research use only. Not for therapeutic Use.
SSK1 (Cat No.:I044697) is a lysosomal β‑galactosidase‑targeted prodrug that selectively eliminates senescent cells. Once activated by elevated β‑galactosidase in senescent cells, SSK1 releases cytotoxic metabolites that trigger p38 MAPK/MKK3/6 phosphorylation, mitochondrial DNA damage, and apoptosis, sparing normal cells . In aged or fibrotic mouse models, low-dose SSK1 reduced senescence-associated β‑gal positive cells, alleviated chronic inflammation, restored tissue function, and improved physical performance without overt toxicity. It shows promise as a senolytic agent for anti-aging and treatment of age-related diseases.
| CAS Number | 2629250-69-5 |
| Synonyms | [(2R,3S,4S,5R,6S)-3,4,5-triacetyloxy-6-[4-[[1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]carbamoyloxymethyl]-2-nitrophenoxy]oxan-2-yl]methyl acetate |
| Molecular Formula | C31H34F2N4O18 |
| Purity | ≥95% |
| IUPAC Name | [(2R,3S,4S,5R,6S)-3,4,5-triacetyloxy-6-[4-[[1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]carbamoyloxymethyl]-2-nitrophenoxy]oxan-2-yl]methyl acetate |
| InChI | InChI=1S/C31H34F2N4O18/c1-13(39)48-12-21-23(50-14(2)40)24(51-15(3)41)25(52-16(4)42)27(54-21)53-19-6-5-17(9-18(19)37(46)47)11-49-30(45)35-22-7-8-36(29(44)34-22)28-31(32,33)26(43)20(10-38)55-28/h5-9,20-21,23-28,38,43H,10-12H2,1-4H3,(H,34,35,44,45)/t20-,21-,23+,24+,25-,26-,27-,28-/m1/s1 |
| InChIKey | DLQYTWCQXUJEML-XERWOCHESA-N |
| SMILES | CC(=O)OC[C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)OC2=C(C=C(C=C2)COC(=O)NC3=NC(=O)N(C=C3)[C@H]4C([C@@H]([C@H](O4)CO)O)(F)F)[N+](=O)[O-])OC(=O)C)OC(=O)C)OC(=O)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
