(S,S)-BMS-984923

• CAT Number: I042495
• CAS Number: 1375752-77-4
• Molecular Formula: C22H15ClN2O2
• Molecular Weight: 374.82
• Purity: ≥95%
• Synonyms: (4S,5S)-5-(2-chlorophenyl)-4-[5-(2-phenylethynyl)pyridin-3-yl]-1,3-oxazolidin-2-one
• InChI: InChI=1S/C22H15ClN2O2/c23-19-9-5-4-8-18(19)21-20(25-22(26)27-21)17-12-16(13-24-14-17)11-10-15-6-2-1-3-7-15/h1-9,12-14,20-21H,(H,25,26)/t20-,21-/m0/s1
• InChIKey: IAYVUQJOKDFLAL-SFTDATJTSA-N
• SMILES: C1=CC=C(C=C1)C#CC2=CC(=CN=C2)C3C(OC(=O)N3)C4=CC=CC=C4Cl

(S,S)-BMS-984923 (Cat No.: I042495) is a selective androgen receptor modulator (SARM) developed to target androgen receptors with tissue-specific activity. Designed to promote anabolic effects in muscle and bone while minimizing androgenic effects in tissues like the prostate, it offers therapeutic potential for conditions such as muscle wasting, osteoporosis, and hypogonadism. The (S,S)-enantiomer ensures stereochemical precision for optimized receptor binding and efficacy. BMS-984923 is a valuable research tool for studying androgen receptor signaling and advancing safer alternatives to traditional androgen therapies.

Reference

[1]. Andrew P. Degnan, et al. Oxazolidinones as modulators of mglur5. WO2012064603A1.

[2]. Laura T Haas, et al. Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer’s Mouse Phenotypes. Cell Rep. 2017 Jul 5;20(1):76-88.
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