For research use only. Not for therapeutic Use.
(S,R,S)-AHPC-phenol-C4-NH2 dihydrochloride（Cat No.:I015239）is a synthetic ligand derivative of the AHPC scaffold, frequently employed in the design of proteolysis-targeting chimeras (PROTACs). Featuring a phenol group and a C4-amino linker, this compound facilitates conjugation to target-binding ligands, enabling selective recruitment of the von Hippel–Lindau (VHL) E3 ubiquitin ligase. The dihydrochloride salt enhances solubility and handling for biological applications. This versatile intermediate is widely used in chemical biology and drug discovery to develop targeted protein degraders, providing a powerful strategy for exploring novel therapeutic approaches.
| CAS Number | 2376990-26-8 |
| Synonyms | (2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-N-[[2-(4-aminobutoxy)-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-hydroxypyrrolidine-2-carboxamide;dihydrochloride |
| Molecular Formula | C28H43Cl2N5O5S |
| Purity | ≥95% |
| IUPAC Name | (2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-N-[[2-(4-aminobutoxy)-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-hydroxypyrrolidine-2-carboxamide;dihydrochloride |
| InChI | InChI=1S/C28H41N5O5S.2ClH/c1-17-24(39-16-31-17)19-8-9-20(23(12-19)38-11-7-6-10-29)14-30-26(36)22-13-21(35)15-33(22)27(37)25(28(3,4)5)32-18(2)34;;/h8-9,12,16,21-22,25,35H,6-7,10-11,13-15,29H2,1-5H3,(H,30,36)(H,32,34);2*1H/t21-,22+,25-;;/m1../s1 |
| InChIKey | LDWASNPVOMODPJ-OTCWRJAQSA-N |
| SMILES | CC1=C(SC=N1)C2=CC(=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)C)O)OCCCCN.Cl.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
