For research use only. Not for therapeutic Use.
(S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride（Cat No.:I015240）is a functionalized AHPC derivative designed for use in proteolysis-targeting chimera (PROTAC) development. Incorporating a phenolic group and a six-carbon alkyl amine linker, it enables flexible conjugation to ligands of target proteins while recruiting the VHL E3 ubiquitin ligase. The dihydrochloride salt form improves solubility and stability for biological applications. This intermediate is widely employed in chemical biology and drug discovery to construct selective protein degraders, advancing research into targeted degradation strategies and therapeutic innovations across oncology and beyond.
| CAS Number | 2376990-28-0 |
| Synonyms | (2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-N-[[2-(6-aminohexoxy)-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-hydroxypyrrolidine-2-carboxamide;dihydrochloride |
| Molecular Formula | C30H47Cl2N5O5S |
| Purity | ≥95% |
| IUPAC Name | (2S,4R)-1-[(2S)-2-acetamido-3,3-dimethylbutanoyl]-N-[[2-(6-aminohexoxy)-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-4-hydroxypyrrolidine-2-carboxamide;dihydrochloride |
| InChI | InChI=1S/C30H45N5O5S.2ClH/c1-19-26(41-18-33-19)21-10-11-22(25(14-21)40-13-9-7-6-8-12-31)16-32-28(38)24-15-23(37)17-35(24)29(39)27(30(3,4)5)34-20(2)36;;/h10-11,14,18,23-24,27,37H,6-9,12-13,15-17,31H2,1-5H3,(H,32,38)(H,34,36);2*1H/t23-,24+,27-;;/m1../s1 |
| InChIKey | ZDPHPLMGGQWIRY-SGROTYDGSA-N |
| SMILES | CC1=C(SC=N1)C2=CC(=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)C)O)OCCCCCCN.Cl.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
