(S,R,S)-AHPC-PEG5-COOH

• CAT Number: I017715
• CAS Number: 2172820-14-1
• Molecular Formula: C36H54N4O11S
• Molecular Weight: 750.90
• Purity: ≥95%
• Synonyms: 3-[2-[2-[2-[2-[3-[[(2S)-1-[(2S,4R)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C36H54N4O11S/c1-25-32(52-24-38-25)27-7-5-26(6-8-27)22-37-34(45)29-21-28(41)23-40(29)35(46)33(36(2,3)4)39-30(42)9-11-47-13-15-49-17-19-51-20-18-50-16-14-48-12-10-31(43)44/h5-8,24,28-29,33,41H,9-23H2,1-4H3,(H,37,45)(H,39,42)(H,43,44)/t28-,29+,33-/m1/s1
• InChIKey: YDOJYEPMGKGKQV-ZLWRCJDJSA-N
• SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)CCOCCOCCOCCOCCOCCC(=O)O)O

(S,R,S)-AHPC-PEG5-COOH (CAT: I017715) is a synthetic E3 ligase ligand-linker conjugate designed for use in PROTAC (proteolysis-targeting chimera) technology. It features the (S,R,S)-AHPC-based VHL ligand, which binds to the von Hippel–Lindau (VHL) E3 ubiquitin ligase, connected via a five-unit PEG linker terminating in a carboxylic acid group for target conjugation. This bifunctional intermediate enables the creation of heterobifunctional molecules that recruit target proteins to the ubiquitin–proteasome system for selective degradation. Owing to its optimal linker length and chemical versatility, (S,R,S)-AHPC-PEG5-COOH serves as a key building block in PROTAC design and structure–activity optimization.