For research use only. Not for therapeutic Use.
(S,R,S)-AHPC-O-Ph-PEG1-NH2(CAT: I016934) is a hydroxyproline-derived cereblon (CRBN) ligand engineered for use in PROTAC (proteolysis-targeting chimera) and molecular glue design. This derivative features the AHPC pharmacophore with defined (S,R,S) stereochemistry, ensuring strong and selective binding to the E3 ligase CRBN. It is functionalized with a phenoxy-PEG1 linker terminating in a primary amine, which serves as a reactive handle for conjugation with carboxylic acids, activated esters, or other complementary groups. The short PEG1 spacer enhances solubility and provides minimal steric hindrance, making this reagent particularly useful in the synthesis of tailored bifunctional degraders for targeted protein degradation research.
| CAS Number | 2361117-24-8 |
| Synonyms | (2S,4R)-1-[(2S)-2-[[2-[4-(2-aminoethoxy)phenoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide |
| Molecular Formula | C32H41N5O6S |
| Purity | ≥95% |
| IUPAC Name | (2S,4R)-1-[(2S)-2-[[2-[4-(2-aminoethoxy)phenoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide |
| InChI | InChI=1S/C32H41N5O6S/c1-20-28(44-19-35-20)22-7-5-21(6-8-22)16-34-30(40)26-15-23(38)17-37(26)31(41)29(32(2,3)4)36-27(39)18-43-25-11-9-24(10-12-25)42-14-13-33/h5-12,19,23,26,29,38H,13-18,33H2,1-4H3,(H,34,40)(H,36,39)/t23-,26+,29-/m1/s1 |
| InChIKey | UWILAIJPPCISSY-ZSOKXDGFSA-N |
| SMILES | CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)COC4=CC=C(C=C4)OCCN)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
