(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2

• CAT Number: I045757
• CAS Number: 2409538-69-6
• Molecular Formula: C31H47N5O7S
• Molecular Weight: 633.80
• Purity: ≥95%
• Synonyms: (2S,4R)-1-[(2S)-2-[[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
• InChI: InChI=1S/C31H47N5O7S/c1-20(22-6-8-23(9-7-22)27-21(2)33-19-44-27)34-29(39)25-16-24(37)17-36(25)30(40)28(31(3,4)5)35-26(38)18-43-15-14-42-13-12-41-11-10-32/h6-9,19-20,24-25,28,37H,10-18,32H2,1-5H3,(H,34,39)(H,35,38)/t20-,24+,25-,28+/m0/s1
• InChIKey: SIIIUIAOOHNPNB-MPLXTJOBSA-N
• SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)[C@H](C)NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)COCCOCCOCCN)O

(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2（Cat No.:I045757）is a heterobifunctional ligand derivative used in targeted protein degradation research, particularly in the design of PROTACs (proteolysis-targeting chimeras). It features an AHPC-based moiety that binds to the von Hippel–Lindau (VHL) E3 ubiquitin ligase, connected via a PEG3 linker terminating in a primary amine. This functional handle allows conjugation to ligands for proteins of interest, enabling recruitment to VHL and subsequent ubiquitination. Its structural design supports modular PROTAC synthesis, facilitating studies on protein turnover, signaling pathways, and therapeutic discovery in cancer and beyond.