For research use only. Not for therapeutic Use.
(S,R,S)-AHPC-Me-C10-Br(CAT: I046010) is a synthetic E3 ligase ligand-linker conjugate designed for targeted protein degradation research. This compound incorporates a VHL E3 ligase ligand connected via a C10 alkyl-bromide linker to MS432, a derivative of the MEK1/2 inhibitor PD0325901. By bridging a selective kinase inhibitor with an E3 ligase recruiter, (S,R,S)-AHPC-Me-C10-Br functions as a versatile building block for the development of PROTACs (proteolysis-targeting chimeras). Its modular design enables the exploration of MEK1/2 degradation, providing a valuable tool for studying RAS/MAPK signaling pathways, oncology targets, and next-generation therapeutic strategies in cancer biology.
| CAS Number | 2836297-55-1 |
| Synonyms | (2S,4R)-1-[(2S)-2-(11-bromoundecanoylamino)-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide |
| Molecular Formula | C34H51BrN4O4S |
| Purity | ≥95% |
| IUPAC Name | (2S,4R)-1-[(2S)-2-(11-bromoundecanoylamino)-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide |
| InChI | InChI=1S/C34H51BrN4O4S/c1-23(25-15-17-26(18-16-25)30-24(2)36-22-44-30)37-32(42)28-20-27(40)21-39(28)33(43)31(34(3,4)5)38-29(41)14-12-10-8-6-7-9-11-13-19-35/h15-18,22-23,27-28,31,40H,6-14,19-21H2,1-5H3,(H,37,42)(H,38,41)/t23-,27+,28-,31+/m0/s1 |
| InChIKey | DYDLRAYTCZUFBG-GOGGMHKJSA-N |
| SMILES | CC1=C(SC=N1)C2=CC=C(C=C2)C(C)NC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)CCCCCCCCCCBr)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
