(S,R,S)-AHPC-CO-C9-acid

• CAT Number: I031826
• CAS Number: 2172819-78-0
• Molecular Formula: C33H48N4O6S
• Molecular Weight: 628.82
• Purity: ≥95%
• Synonyms: 11-[[(2S)-1-[(2S,4R)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-11-oxoundecanoic acid
• InChI: InChI=1S/C33H48N4O6S/c1-22-29(44-21-35-22)24-16-14-23(15-17-24)19-34-31(42)26-18-25(38)20-37(26)32(43)30(33(2,3)4)36-27(39)12-10-8-6-5-7-9-11-13-28(40)41/h14-17,21,25-26,30,38H,5-13,18-20H2,1-4H3,(H,34,42)(H,36,39)(H,40,41)/t25-,26+,30-/m1/s1
• InChIKey: MTQZLQCVZFDQOZ-DIIXFEDBSA-N
• SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCCCCCCC(=O)O)O

(S,R,S)-AHPC-CO-C9-acid（Cat No.:I031826）is a derivative of AHPC (aryl hydrocarbon receptor-binding compound) modified with a C9 aliphatic acid linker, commonly used as a ligand for von Hippel–Lindau (VHL) E3 ubiquitin ligase in the design of PROTACs (proteolysis-targeting chimeras). This compound enables the recruitment of VHL to a target protein, facilitating its ubiquitination and proteasomal degradation. The (S,R,S) stereochemistry ensures optimal binding affinity and functional orientation for targeted protein degradation. It is a valuable tool in chemical biology and drug discovery for modulating disease-related proteins through targeted degradation strategies.