(S,R,S)-AHPC-C3-NH2 dihydrochloride

• CAT Number: I038031
• CAS Number: 2564467-25-8
• Molecular Formula: C26H39Cl2N5O4S
• Molecular Weight: 588.59
• Purity: ≥95%
• Synonyms: (2S,4R)-1-[(2S)-2-(4-aminobutanoylamino)-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide;dihydrochloride
• InChI: InChI=1S/C26H37N5O4S.2ClH/c1-16-22(36-15-29-16)18-9-7-17(8-10-18)13-28-24(34)20-12-19(32)14-31(20)25(35)23(26(2,3)4)30-21(33)6-5-11-27;;/h7-10,15,19-20,23,32H,5-6,11-14,27H2,1-4H3,(H,28,34)(H,30,33);2*1H/t19-,20+,23-;;/m1../s1
• InChIKey: WMBHSWGXRVCMQP-YEMZLKFISA-N
• SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)CCCN)O.Cl.Cl

(S,R,S)-AHPC-C3-NH₂ dihydrochloride(CAT: I038031) is a high-affinity ligand based on the AHPC (aryl hydrocarbon receptor-binding protein complex) scaffold, often utilized as a functionalized E3 ligase-recruiting moiety in PROTAC (proteolysis-targeting chimera) design. Featuring a chiral, amine-terminated C3 linker, this compound facilitates site-specific conjugation to target-binding warheads, enabling selective degradation of intracellular proteins via the ubiquitin-proteasome system. Its dihydrochloride salt form enhances solubility and stability for biological applications. (S,R,S)-AHPC-C3-NH₂ is an essential intermediate for structure–activity relationship (SAR) exploration in targeted protein degradation research, offering a powerful tool for advancing chemical biology, oncology, and drug discovery pipelines.

Reference

[1]. Potjewyd F, et al. Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader. Cell Chem Biol. 2020 Jan 16;27(1):47-56.e15.
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