For research use only. Not for therapeutic Use.
(S,R,S)-AHPC-C1-NH2 hydrochloride（Cat No.:I044465）is an amine-functionalized analog of AHPC designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). The compound features a terminal amine group (C1-NH2) for facile conjugation to ligands targeting proteins of interest, while the (S,R,S) stereochemistry ensures high-affinity binding to the VHL (von Hippel–Lindau) E3 ubiquitin ligase. The hydrochloride salt form improves solubility and handling for chemical synthesis. (S,R,S)-AHPC-C1-NH2 hydrochloride is a valuable building block for developing bifunctional molecules that promote selective protein degradation, supporting research in chemical biology and targeted therapeutics.
| CAS Number | 2361120-26-3 |
| Synonyms | (2S,4R)-1-[(2S)-2-[(2-aminoacetyl)amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide;hydrochloride |
| Molecular Formula | C24H34ClN5O4S |
| Purity | ≥95% |
| IUPAC Name | (2S,4R)-1-[(2S)-2-[(2-aminoacetyl)amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide;hydrochloride |
| InChI | InChI=1S/C24H33N5O4S.ClH/c1-14-20(34-13-27-14)16-7-5-15(6-8-16)11-26-22(32)18-9-17(30)12-29(18)23(33)21(24(2,3)4)28-19(31)10-25;/h5-8,13,17-18,21,30H,9-12,25H2,1-4H3,(H,26,32)(H,28,31);1H/t17-,18+,21-;/m1./s1 |
| InChIKey | RDVLBRLCBGVZQV-UTYHKCQPSA-N |
| SMILES | CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CN)O.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
