For research use only. Not for therapeutic Use.
(S,R,S)-AHPC-C1-Br（Cat No.:I044464）is a functionalized analog of AHPC (aryl hydrocarbon receptor-binding compound) designed for use in PROTAC (proteolysis-targeting chimera) development. It features a bromoalkyl (C1-Br) moiety, enabling covalent conjugation to ligands targeting proteins of interest. The (S,R,S) stereochemistry ensures optimal binding to the von Hippel–Lindau (VHL) E3 ubiquitin ligase, promoting effective recruitment and targeted ubiquitination of bound proteins. (S,R,S)-AHPC-C1-Br is widely used in the design of bifunctional molecules aimed at degrading pathogenic or disease-relevant proteins, supporting research in targeted protein degradation and drug discovery applications.
| CAS Number | 2379404-33-6 |
| Synonyms | (2S,4R)-1-[(2S)-2-[(2-bromoacetyl)amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide |
| Molecular Formula | C24H31BrN4O4S |
| Purity | ≥95% |
| IUPAC Name | (2S,4R)-1-[(2S)-2-[(2-bromoacetyl)amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide |
| InChI | InChI=1S/C24H31BrN4O4S/c1-14-20(34-13-27-14)16-7-5-15(6-8-16)11-26-22(32)18-9-17(30)12-29(18)23(33)21(24(2,3)4)28-19(31)10-25/h5-8,13,17-18,21,30H,9-12H2,1-4H3,(H,26,32)(H,28,31)/t17-,18+,21-/m1/s1 |
| InChIKey | YJWUYJKFKGUQHL-LVCYWYKZSA-N |
| SMILES | CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CBr)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
