For research use only. Not for therapeutic Use.
(S,R,S)-AHPC-amido-C5-acid(CAT: I016940) is a functionalized derivative of AHPC (hydroxyproline-based ligand for the E3 ligase cereblon, CRBN) widely applied in targeted protein degradation research. This molecule contains the AHPC pharmacophore, which engages CRBN, linked via an amide bond to a pentyl (C5) spacer terminating in a carboxylic acid. The terminal acid serves as a versatile handle for coupling with amines or other reactive groups, making it ideal for constructing PROTACs (proteolysis-targeting chimeras) and related bifunctional molecules. The defined stereochemistry (S,R,S) ensures high binding affinity and selectivity toward CRBN, enabling precise exploration of ubiquitin-mediated protein degradation pathways.
| CAS Number | 2162120-87-6 |
| Synonyms | 7-[[(2S)-1-[(2S,4R)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-7-oxoheptanoic acid |
| Molecular Formula | C29H40N4O6S |
| Purity | ≥95% |
| IUPAC Name | 7-[[(2S)-1-[(2S,4R)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-7-oxoheptanoic acid |
| InChI | InChI=1S/C29H40N4O6S/c1-18-25(40-17-31-18)20-12-10-19(11-13-20)15-30-27(38)22-14-21(34)16-33(22)28(39)26(29(2,3)4)32-23(35)8-6-5-7-9-24(36)37/h10-13,17,21-22,26,34H,5-9,14-16H2,1-4H3,(H,30,38)(H,32,35)(H,36,37)/t21-,22+,26-/m1/s1 |
| InChIKey | LYAMSRXTXVKKIC-TVZXLZGTSA-N |
| SMILES | CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)CCCCCC(=O)O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
