For research use only. Not for therapeutic Use.
SR17018(CAT: I014687) is a potent and selective μ-opioid receptor (MOR) agonist with an EC₅₀ of 97 nM in GTPγS binding assays, indicating strong activation of G protein-coupled signaling pathways. Notably, SR17018 does not induce significant β-arrestin2 recruitment at concentrations below 10 μM, demonstrating a functionally biased profile favoring G protein signaling over β-arrestin-mediated pathways. This bias is of particular interest in opioid research, as it may reduce adverse effects such as respiratory depression and tolerance. SR17018 serves as a valuable tool compound for investigating biased agonism at the MOR and for the development of next-generation, safer analgesics.
| CAS Number | 2134602-45-0 |
| Synonyms | 5,6-dichloro-3-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-1H-benzimidazol-2-one |
| Molecular Formula | C19H18Cl3N3O |
| Purity | ≥95% |
| IUPAC Name | 5,6-dichloro-3-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-1H-benzimidazol-2-one |
| InChI | InChI=1S/C19H18Cl3N3O/c20-13-3-1-12(2-4-13)11-24-7-5-14(6-8-24)25-18-10-16(22)15(21)9-17(18)23-19(25)26/h1-4,9-10,14H,5-8,11H2,(H,23,26) |
| InChIKey | LAGUDYUGRSQDKS-UHFFFAOYSA-N |
| SMILES | C1CN(CCC1N2C3=CC(=C(C=C3NC2=O)Cl)Cl)CC4=CC=C(C=C4)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
